Specificity: This antibody reacts with Vgamma 2 T-Cell Receptor (TCR)-bearing T lymphocytes.

Endotoxin Level: <1.0 EU/mg as determined by the LAL method.

Purity: ≥95% monomer by analytical SEC and >95% by SDS Page.

Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Storage: This antibody is stable for at least one week when stored sterile at 2-8C. For long term storage aseptically aliquot in working volumes without diluting and store at -20C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

該抗體在2-8C無(wú)菌儲(chǔ)存時(shí)至少穩(wěn)定一周。用于長(zhǎng)期無(wú)菌儲(chǔ)存，按工作體積等分，無(wú)需稀釋?zhuān)⒃?20℃的手動(dòng)除霜冰箱中儲(chǔ)存。避免反復(fù)凍融循環(huán)。

靶標(biāo)信息

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.僅用于科研。不用于診斷過(guò)程。未經(jīng)明確授權(quán)不得轉(zhuǎn)售。